Abkürzungen
ACMG – American College of Medical Genetics and Genomics
ADC – Antikörper-Wirkstoff-Konjugat
AMP – Association for Molecular Pathology
BRCA – Breast Cancer
CDK4/6 – Cyclin-Dependent Kinases 4 und 6
CPS – Combined Positive Score
EGFR – Epidermal Growth Factor Receptor
EMA – European Medicines Agency
ER/PR – Östrogenrezeptor/Progesteronrezeptor
GenDG – Gendiagnostikgesetz
GnRH – Gonadotropin-Releasing-Hormon
HER2 – Human Epidermal growth factor Receptor 2
HR – Hormonrezeptor
HGVS – Human Genome Variant Society
IARC – International Agency for Research on Cancer
IC – Immune Cell
ICI – Immuncheckpoint-Inhibitoren
IHC – Immunhistochemie
IKWG – The International Ki67 in Breast Cancer Working Group
ISH – In-situ-Hybridisierung
Ki67 – Antigen KI-67
MAPK – Mitogen-Activated Protein Kinase
mBC – metastasiertes Mammakarzinom
MCC – MCC Brücke
mTNBC – metastasierter triple-negativer Brustkrebs
NGS – Next Generation Sequencing
NSCLC – Non Small Cell Lung Cancer
PARP – Poly-ADP-Ribose-Polymerase
PD-1 – Programmed Death Protein 1
PD-L1 – Programmed Cell Death Ligand 1
PI3K – Phosphotidylinositol-3-Kinase
PTEN – Phosphatase und TENsin homolog
QuIP – Qualitätssicherungs-Initiative Pathologie GmbH
SERM – Selektiver Modulator von Östrogenrezeptoren (SERM)
SLNB – Sentinel-Lymphknotenen-Biopsie
SOP – Standard Operating Procedure
TNBC – Triple Negative Breast Cancer
VUS – Variants of Unknown Significance